Phenolic compounds slow breast cancer cell growth

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Scientific update

Phenolic compounds slow breast cancer cell growth

In more news from the Experimental Biology 2004 meeting, held April 17 to 21 in Washington, DC, S. Pinheiro-Silva, I. Azevedo, and C. Calhau from the Universidade do Porto, in Portugal have shown that the phenolic phytochemicals epigallocatechin gallate (EGCG), xanthohumol, and resveratrol slow breast cancer growth in human cell cultures. The compounds are found in tea, beer, and wine respectively, a fact that appears to contradict the results of previous research that established an association between alcohol consumption and an increased risk of breast cancer in women. However, the researchers caution that the findings of this study do not suggest that women increase alcohol consumption. The Portuguese team cultured breast cancer cells in the presence of varying concentrations of EGCG, xanthohumol and resveratrol for various periods of time. At the end of each treatment period the number of cells and the ratio between dead and live cells was calculated. In other experiments, 3H-thymidine incorporation was evaluated, which measured the effect of each treatment on DNA synthesis. It was discovered that all of the compounds possessed an inhibitory effect on breast cancer cell growth, with xanthohumol eliciting an antiproliferative effect more rapidly and at a lower concentration than the other compounds. Although EGCG demonstrated the lowest potency of the compounds tested, it also showed the least cytotoxicity , meaning that it can be administered in higher doses. A decrease in 3H-thymidine incorporation was also observed in the presence of the phenolic compounds. The authors conclude that the findings support epidemiological studies that relate consumption of specific beverages with a lesser incidence of cancer and that clinical studies are needed to support recommending the compounds as cancer preventives.

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